2016-05-09 15:52
The Chinese herbal medicine industry unspoken rule is revealed: Harbin pharmaceutical companies sell sour shellfish
[straight news network Beijing, May 9 news] (economic information daily) recently, have received complaints reflect, due to the use of sulfur fumigation of Zhebei as raw materials, a lot of finished drug was detected a higher sulfur content, the Tai Chi Group, through medicine group, Harbin Pharmaceutical Group, Yunnan Baiyao group several well-known pharmaceutical companies or involved. The economic reference newspaper reporters rushed to Zhejiang, Anhui and other places survey found, sulfur fumigation fritillary like pharmaceutical industry "the melamine, has become the unspoken rules of the Chinese herbal medicine industry, and the lack of testing standards let the unspoken rule of development become clear rules. Industry experts called for the introduction of finished product testing standards for sulfur content has become a priority.
A variety of drug testing found that sulfur is not involved in the response to the enterprise
According to reports, Zhejiang Fritillaria Bulb, alias Thunberg Fritillary Bulb, like shellfish, big Fritillaria is a for clearing heat and resolving phlegm, lungs and cough medicines, and largehead atractylodes rhizome, white paeony root etc. are collectively referred to as "zhebawei". According to informants White told the reporters, sulfur fumigation of fritillary bulb on the human body harm is great, the drug in order to test market the sale to the public whether there is excessive sulfur, at the end of last year he buys 5 kinds of common cough and phlegm drugs and sent to a third-party testing agencies. As a result, people eat a surprised: all inspection drugs were detected in the sulfur content.
According to the issued white one provided Xi'an Guolian quality detection technology Limited by Share Ltd inspection report and retained samples, the reporter found that the detection of 5 kinds of drug sulfur content were: two Taiji Group Chongqing Chinese Medicine Factory Limited production of Juhong pill, Zhunzi Z20027420, specifications for 3G x 9 bags, the test result is 0.6%; through the production of Limited by Share Ltd pharmaceutical group of Juhong pill, Zhunzi Z22023402, specifications for 6G x 10 pill, the test result is 0.3%; also through Pharmaceutical Group Limited by Share Ltd production of runfeizhisou pill, Zhunzi Z20093622, specifications for 8g x 12 bags, the test result is 0.2%; the production of Shiyitang pharmaceutical factory Harbin Pharmaceutical Group Jinbei tankeqing granules, Zhunzi Z10950032, specifications for 7g x 10 bags, test results for 0.1% children with Bao Taikang; a Limited by Share Ltd of Yunnan Baiyao group. Tablets, the national standard word Z10920006, specifications for 4G x 12 bags, the detection result is 0.1%. Responsible for detection Zhong Mou thinks, generally speaking, the drug product components should not "sulfur" ingredients, and these 5 kinds of cough medicine in 100 grams of refined medicine highest actually contains 0.6 grams of sulfur (i.e. six thousandths of proportion), least also 0.1 grams of sulfur, which is really surprising.
It is understood, the five kinds of cough medicine sulfur content detection basis is standard for the detection of sulfur content in the national food safety standards, is currently in effect in 2010 the Ministry of Health issued the "the people's Republic of China national standard GB3150-2010 Appendix A and detection mechanism with reference to the detection method of the standard gauge.
But it is worth noting that the Xi'an National Union is not the official drug testing institutions in China, so the results need to be further confirmed official. But the results, President of the China Association of traditional Chinese medicine, the former State Administration of traditional Chinese medicine, deputy director of the room bookstall told the economic reference news reporter said in Pharmacopoeia of people's Republic of China for the content of the traditional Chinese medicine does not exist in the sulfur compounds. At the same time, for the better drying of Fritillaria thunbergii is never allowed to use sulfur fumigation dry. "This means that used Fritillaria medicinal materials in traditional Chinese medicine, also should not appear any sulfur containing substances, if in accordance with the provisions previously relaxed, its content should be below 150 mg / kg."
The economic reference news reporter the drug sulfur standard recently contacted the four pharmaceutical companies interview, concurrent to the written interview outline, but as of press time all did not receive a reply.
The market for the sale of sulfur containing sulfur ban Cheng Kongwen
It is worth noting that the reason for the high sulfur content in Chinese traditional medicine is raw materials, and the use of sulfur fumigation drying is the main way to enter the Chinese herbal medicine.
It is reported that the Chinese herbal medicine treatment containing raw material was detected above exceed the standard of drug ingredients in sulfur. The main studies the origin of Zhejiang County of Panan Province, located in the county's new market is the largest distributing center of fritillaria. Not long ago, the economic reference news reporter repeatedly visited the site of distance Panan county 10 kilometers away, is known as one of the East China are the largest distributing center of Chinese herbal medicines of the new Ottawa market.
Let reporters very surprised is that the new market was actually in the public sale of sour shellfish. In crowded trading reporters at the scene saw, stall made no secret of his sale of Fritillaria thunbergii is after sulfur fumigation that Thunberg Fritillary Bulb is blatantly into sulfur shellfish and sulfur free bay two, white is sulfur Bei, gray hair is no sulfur shellfish and sulfur Bay's price is significantly higher in sulfur Bay. A Chen vendors frankly told reporters that no sulfur simply couldn't help, he Zhebei year sent out about 300 tons, about half of them are after sulfur fumigation.
According to people familiar with the matter, every new Ottawa market each month lunar two, five, eight, about nine trading days, according to the new Ottawa market turnover statistics, nearly nine trading days of each trading day average turnover of Zhebei about 25 tons, which sulfur bay for about 18 tons. Analysis of the industry, coupled with the omission of some statistics, a total of more than a month more than 300 tons, of which at least more than half of sulfur bearing bay to the national market, most of which eventually entered the Chinese medicine and traditional Chinese medicine retail stores.
Reporter's inquiry to the State Food and Drug Administration website to see such a statement: in crude drug and different in food, the intake is relatively small and by volatile sulfur dioxide residue after sulfur fumigation of Chinese herbal medicine and traditional Chinese medicine Yinpian, after the medicine storage and other aspects of the, residue will be further reduced, a small amount of sulfur dioxide into the body will not cause harm.
However, because sulfur fumigation does not mean no problem, which is the country's main reason for the strict control of sulfur fumigation. On the one hand is due to sulfur fumigation herbs hyperchromic, whitening, so some unscrupulous businessmen can in order to achieve shoddy effect. On the other hand, excessive use of sulfur fumigation of Chinese herbal medicine, its sulfur dioxide residue is too high, it will damage the body's digestive system and respiratory system, the liver, kidney and other organs also have a potential threat.
Therefore, in our country the the people's Republic of China Pharmacopoeia (2000 EDITION) has been specified, except yam all other Chinese herbal medicine drug not fumigated with sulfur or immersion, 2005 edition of "Chinese Pharmacopoeia" deleted some of the medicinal material in the process of using sulfur fumigation and steaming method, and gradually began to prohibit the sulfur smoked method used for bleaching, brightening and pest control. Released in 2013 "Chinese Pharmacopoeia (2010 version of the second supplement to" the, provides for the first time in crude drug and sulfur dioxide residue limit standards, strict rules sulfur fumigating medicine varieties can be used, and pointed out that the sulfur dioxide residue shall not exceed 400mg / kg and other Chinese herbal medicines and pieces of sulfur dioxide residue shall not exceed 150 mg / kg, overrun in crude drug and will punished for medicines of inferior quality, serious will be held criminal responsibility.
Fang Shuting, first solve allows the use of sulfur fumigation herbs only 10 kinds, respectively is the yam, Achyranthes root, kudzu root, asparagus root, gastrodia tuber, Radix trichosanthis, Rhizoma Bletillae, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae and Radix Codonopsis. "Deployed by the State Food and drug administration, of Chinese crude drugs in the sulfur dioxide residual amount detection method and a limited research project, the provisions allow the 10 has yet to find better drying method and storage method of Chinese herbal medicines in a certain dose fumigation with sulfur. In addition, any Chinese herbal medicines prohibited use sulfur to dry."
If the monthly purchase of 200 tons of sulfur bearing
Enterprises can save costs 3 million 600 thousand yuan
It is worth noting that pharmaceutical companies are not do not understand the harm of sulfur procurement of fritillaria. According to the vendors, more sulfur is used in traditional Chinese medicine fritillaria. "Several species of Fritillaria, used directly as a medicinal drugs due to more stringent checks, there is almost no sulfur Fritillaria by."
Under the ban, why there are still so many of the sulfur content of the public into the market, the industry analysts believe that the use of sulfur fumigation can reduce the cost of pharmaceuticals is the main reason.
It is understood, with sulfur of medicine of fumigation can play a role in two aspects, not only can make the drug whitening, but also to achieve the mildew, insecticidal effect. Because the sulfur in the fumigation in burning sulfur dioxide gas, sulfur dioxide itself is a strong reducing agent, the chemical reaction with the medicinal materials in the water can be generated acid, to mold, anti moth eaten, while promoting the dry herbs, medicinal herbs for storage. Reflect the local Beynon, fresh Fritillaria generally with sulfur smoked, steamed for two days and two nights, and then in the sun drying for three or four days will become sulfur fumigation Fritillaria thunbergii.
Fang Shuting, said a hundred years ago, people found that sulfur fumigation of Chinese herbal medicine is easy and dry, not easy to get damp, so difficult to dry part of the Chinese herbal medicine using sulfur fumigation dry method. But because of material demand, in order to reduce the time, reduce the cost, increase the use of sulfur smoked varieties.
As these insiders said, using sulfur fumigation treatment can indeed much lower price. The economic reference news reporter login herbs trading site in heaven and earth of the medicinal material, click on the "Zhejiang Fritillaria species into in the" spot price "plate can clearly see all of Zhejiang fritillary quotation, and where there is sulfur words impressively in the head. As of May 4th, sulfur fritillary offer 64 yuan per kilogram, sulfur free fritillary offer is as high as 82 yuan per kilogram. This calculation, each to buy a ton of sulfur Fritillaria, purchasing cost savings of 18000 yuan. According to the monthly nearly 200 tons of sulfur Fritillaria, pharmaceutical enterprises procurement cost savings of 3 million 600 thousand yuan per month. "Now is not the time difference most, every winter treatment used in season, the difference between the two can be as high as 40 to 50 yuan." Introduction to local people.
In fact, according to insiders, due to the current drug to take government unified bidding procurement, medicine price suppression is more serious, which is also the pharmaceutical companies do everything possible to lower the cost of the main reason. "For example of a drug in Anhui in price is 10 yuan, in Jiangxi tender will be required to reduce 10%, in Henan tender, was again asked to lower and lower, so for all raw materials using high-quality products, it is difficult for enterprises to maintain.
Sulfur content of finished product testing to save space experts called for the introduction of national standards as soon as possible
The economic reference news reporter in Zhejiang interview found that due to the use of sulfur fumigation fritillary bulb is very common, local people only eat fresh Fritillaria, never eat sulfur fumigation of Fritillaria thunbergii. It is understood, sulfur dioxide is toxic chemical substances, long-term exposure to sulfur dioxide residue in Chinese herbal medicine to eat, will cause vomiting, diarrhea, nausea and other symptoms, can seriously damage the liver, kidney, can also cause chronic poisoning, such as chronic rhinitis, pharyngitis, bronchitis, bronchial asthma, emphysema and other, may also improve lung cancer prevalence. Hangzhou City medical specific types of vocational skill identification station, Hangzhou City drug and medical device companies Rights Protection Association released a report showed that if over 500 mu g / kg of sulfur dioxide in Chinese medicinal materials, can make the person produce taste of discomfort, can smell particularly pungent sour in taste, can cause acute cough, acute toxicity reaction including.
The United Nations Food and Agriculture Organization and the World Health Organization combined with food additives expert committee that sulfur dioxide substances as food additives, acceptable daily intake for 0 - / kg body weight, a weight of 60kg adult, sulfur dioxide daily intake may not exceed 42mg. Therefore, the food and Agriculture Organization of the United Nations and the World Health Organization to develop the "general standard for food additives" clearly stipulates that the herbs and spices in sulfite residue amount of sulphur dioxide meter shall not exceed 150 mg / kg ", China's sulfur dioxide residue amount of standards is a reference to this standard. And South Korea and other places on the sulfur content of the higher requirements, such as South Korea's sulfur dioxide content is limited to 30mg/kg.
From reporters on the spot visits to the results of the trading market point of view, the implementation of China's standard effect is not good. Professionals pointed out that put an end to the problem of sulfur fumigation Fritillaria medicinal herbs such as, in addition to multi pronged approach to strengthen the supervision of harvest or habitat processing method from the source, the priority should in the terminal strengthen sulfur detection of a finished drug product.
Due to the lack of national standards, the reporter in the interview process to submission of a finished drug product, sulfur content was the real resistance. Reporter tried to contact the Beijing Municipal Institute of drug inspection, Chinese food and drug testing and research institutes and other units to carry out the detection of sulfur content, but were unable to succeed because of national standards. A province of Jiangsu Province under the jurisdiction of the city food and drug supervision and administration, who asked not to be named person in charge told reporters, at present the country but the provisions of the of Chinese herbal medicines and pieces of sulfur content standard (to sulfur dioxide residues), did not specify the finished medicine residue of sulfur dioxide standard and therefore did not detect the basis and most units also does not have testing tools and conditions.
In this regard, Gansu Agricultural University Professor Chen Yuan and other experts in accept the economic reference news reporter interviewed said that our country of sulfur as a food additive in food and Chinese herbal medicine and herbal residues were clear limits, but drug products of sulfur content standard is still blank, to be introduced national standards. Industry experts also called, increase scientific and technological innovation, as soon as possible to develop alternative method for rapid detection of sulfur-containing compounds in the new method of sulfur smoked herbal medicines and drugs, to better meet the social demand.
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